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CD8(+) T cells recognizing a neuron-restricted antigen injure axons in a model of multiple sclerosis
CD8(+) T cells outnumber CD4(+) cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessary but not sufficient for disease progression i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617772/ https://www.ncbi.nlm.nih.gov/pubmed/37676734 http://dx.doi.org/10.1172/JCI162788 |