Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

The PI3K/AKT/mTOR pathway is commonly dysregulated in cancer. Rapalogs exhibit modest clinical benefit, likely owing to their lack of effects on 4EBP1. We hypothesized that bi-steric mTORC1-selective inhibitors would have greater potential for clinical benefit than rapalogs in tumors with mTORC1 dys...

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Detalles Bibliográficos
Autores principales: Du, Heng, Yang, Yu Chi, Liu, Heng-Jia, Yuan, Min, Asara, John M., Wong, Kwok-Kin, Henske, Elizabeth P., Singh, Mallika, Kwiatkowski, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617776/
https://www.ncbi.nlm.nih.gov/pubmed/37909334
http://dx.doi.org/10.1172/JCI167861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617776/
https://www.ncbi.nlm.nih.gov/pubmed/37909334
http://dx.doi.org/10.1172/JCI167861

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