Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, w...

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Detalles Bibliográficos
Autores principales: Wang, Xiaobo, Istvanffy, Rouzanna, Ye, Linhan, Teller, Steffen, Laschinger, Melanie, Diakopoulos, Kalliope N., Görgülü, Kıvanç, Li, Qiaolin, Ren, Lei, Jäger, Carsten, Steiger, Katja, Muckenhuber, Alexander, Vilne, Baiba, Çifcibaşı, Kaan, Reyes, Carmen Mota, Yurteri, Ümmügülsüm, Kießler, Maximilian, Gürçınar, Ibrahim Halil, Sugden, Maya, Yıldızhan, Saliha Elif, Sezerman, Osman Uğur, Çilingir, Sümeyye, Süyen, Güldal, Reichert, Maximilian, Schmid, Roland M., Bärthel, Stefanie, Oellinger, Rupert, Krüger, Achim, Rad, Roland, Saur, Dieter, Algül, Hana, Friess, Helmut, Lesina, Marina, Ceyhan, Güralp Onur, Demir, Ihsan Ekin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617783/
https://www.ncbi.nlm.nih.gov/pubmed/37607005
http://dx.doi.org/10.1172/JCI166333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617783/
https://www.ncbi.nlm.nih.gov/pubmed/37607005
http://dx.doi.org/10.1172/JCI166333

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