Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease

BACKGROUND: Cholesterol levels and bile acid metabolism are important drivers of metabolic dysfunction-associated steatohepatitis (MASH) progression. Using a mouse model, we investigated the mechanism by which cholesterol exacerbates MASH and the effect of colestyramine (a bile acid adsorption resin...

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Detalles Bibliográficos
Autores principales: Iwaki, Michihiro, Kessoku, Takaomi, Tanaka, Kosuke, Ozaki, Anna, Kasai, Yuki, Kobayashi, Takashi, Nogami, Asako, Honda, Yasushi, Ogawa, Yuji, Imajo, Kento, Usuda, Haruki, Wada, Koichiro, Kobayashi, Noritoshi, Saito, Satoru, Nakajima, Atsushi, Yoneda, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617934/
https://www.ncbi.nlm.nih.gov/pubmed/37902528
http://dx.doi.org/10.1097/HC9.0000000000000285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617934/
https://www.ncbi.nlm.nih.gov/pubmed/37902528
http://dx.doi.org/10.1097/HC9.0000000000000285

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