Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer’s Disease male mice

Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents directed at mitigating tau aggregation and clearing Aβ1-42, and delivery of growth factor genes (BDNF, FGF2), have ameliorated...

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Detalles Bibliográficos
Autores principales: Xiao, Lan, Yang, Xuyu, Sharma, Vinay Kumar, Abebe, Daniel, Loh, Y. Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618095/
https://www.ncbi.nlm.nih.gov/pubmed/37369719
http://dx.doi.org/10.1038/s41380-023-02135-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618095/
https://www.ncbi.nlm.nih.gov/pubmed/37369719
http://dx.doi.org/10.1038/s41380-023-02135-7

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