Cargando…

Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer’s Disease male mice

Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents directed at mitigating tau aggregation and clearing Aβ1-42, and delivery of growth factor genes (BDNF, FGF2), have ameliorated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Lan, Yang, Xuyu, Sharma, Vinay Kumar, Abebe, Daniel, Loh, Y. Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618095/ https://www.ncbi.nlm.nih.gov/pubmed/37369719 http://dx.doi.org/10.1038/s41380-023-02135-7

Ejemplares similares

Neurotrophic, Gene Regulation, and Cognitive Functions of Carboxypeptidase E-Neurotrophic Factor-α1 and Its Variants
por: Xiao, Lan, et al.
Publicado: (2019)

SUN-260 Dual Role of Carboxypeptidase E in Prohormone Processing and a Novel Neurotrophic Factor Mediating Neuroprotection and Cognitive Functions in Hippocampal CA3 Neurons in Mice
por: Xiao, Lan, et al.
Publicado: (2020)

Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration
por: Fan, Fang-Cheng, et al.
Publicado: (2023)

Neurotrophic Factor-α1/Carboxypeptidase E Functions in Neuroprotection and Alleviates Depression
por: Xiao, Lan, et al.
Publicado: (2022)

Neurotrophic factor-α1, a novel tropin is critical for the prevention of stress-induced hippocampal CA3 cell death and cognitive dysfunction in mice: comparison to BDNF
por: Xiao, Lan, et al.
Publicado: (2021)

Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling
por: Sharma, Vinay Kumar, et al.
Publicado: (2021)

Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling
por: Sharma, Vinay Kumar, et al.
Publicado: (2023)

Carboxypeptidase E-∆N Promotes Proliferation and Invasion of Pancreatic Cancer Cells via Upregulation of CXCR2 Gene Expression
por: Hareendran, Sangeetha, et al.
Publicado: (2019)

CARBOXYPEPTIDASE : III. THE ESTIMATION OF CARBOXYPEPTIDASE AND PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration
por: Tan, Meng-Shan, et al.
Publicado: (2021)

CARBOXYPEPTIDASE : I. THE PREPARATION OF CRYSTALLINE CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Neurotrophic delivery in Alzheimer’s-model mice
por: Konofagou, Elisa, et al.
Publicado: (2015)

A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice
por: Cheng, Y, et al.
Publicado: (2016)

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
por: Hüttenrauch, M, et al.
Publicado: (2016)

Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells
por: Hareendran, Sangeetha, et al.
Publicado: (2022)

CARBOXYPEPTIDASE : II. THE PARTIAL PURIFICATION OF PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer’s Disease Neurodegeneration
por: Honea, Robyn A., et al.
Publicado: (2013)

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease
por: Jiao, S-S, et al.
Publicado: (2016)

Natural Products for Neurodegeneration: Regulating Neurotrophic Signals
por: Uddin, Md Sahab, et al.
Publicado: (2021)

Carboxypeptidase E/NFα1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways
por: Cheng, Yong, et al.
Publicado: (2013)

A novel 40kDa N-terminal truncated carboxypeptidase E splice variant: cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers
por: Yang, Xuyu, et al.
Publicado: (2019)

Neurotrophic factors and hippocampal activity in PTSD
por: Tural, Ümit, et al.
Publicado: (2018)

A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function
por: Cong, Lin, et al.
Publicado: (2017)

Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2013)

Age-Related Neurodegeneration and Memory Loss in Down Syndrome
por: Lockrow, Jason P., et al.
Publicado: (2012)

The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease
por: Pengas, George, et al.
Publicado: (2012)

Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E
por: Woronowicz, Alicja, et al.
Publicado: (2012)

Loss of Prolyl Carboxypeptidase in Two-Kidney, One-Clip Goldblatt Hypertensive Mice
por: Grobe, Nadja, et al.
Publicado: (2015)

Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease
por: Yan, Shaozhen, et al.
Publicado: (2020)

Genes associated with Alzheimer’s disease affecting ischemic neurodegeneration of the hippocampal CA3 region
por: Pluta, Ryszard, et al.
Publicado: (2020)

The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila
por: Lu, Binyan, et al.
Publicado: (2016)

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
por: Datta, Dibyadeep, et al.
Publicado: (2021)

Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis
por: Lee, Jaedong, et al.
Publicado: (2021)

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina
por: Shi, Haoshen, et al.
Publicado: (2020)

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease
por: Liu, Weilin, et al.
Publicado: (2022)

Silencing of Carboxypeptidase E expression inhibits proliferation and invasion of Panc-1 pancreatic cancer cells
por: Lou, Hong, et al.
Publicado: (2022)

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease
por: Embury, Christine M, et al.
Publicado: (2016)

Measurement of carboxypeptidase R by colorimetric assay
por: Komura, H, et al.
Publicado: (2002)

Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease
por: Ji, Lin, et al.
Publicado: (2017)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_tra4re4ov48i4v650me4av72e8