Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus

Age, female sex, and apolipoprotein E4 (E4) are risk factors to develop Alzheimer’s disease (AD). There are three major human apoE isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 decreases AD risk. However, E2 is associated with increased risk and severity of post-traumatic stress di...

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Detalles Bibliográficos
Autores principales: Boutros, Sydney Weber, Zimmerman, Benjamin, Nagy, Sydney C., Unni, Vivek K., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618101/
https://www.ncbi.nlm.nih.gov/pubmed/36732588
http://dx.doi.org/10.1038/s41380-023-01966-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618101/
https://www.ncbi.nlm.nih.gov/pubmed/36732588
http://dx.doi.org/10.1038/s41380-023-01966-8

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