Using graph-based model to identify cell specific synthetic lethal effects

Synthetic lethal (SL) pairs are pairs of genes whose simultaneous loss-of-function results in cell death, while a damaging mutation of either gene alone does not affect the cell’s survival. This makes SL pairs attractive targets for precision cancer therapies, as targeting the unimpaired gene of the...

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Detalles Bibliográficos
Autores principales: Pu, Mengchen, Cheng, Kaiyang, Li, Xiaorong, Xin, Yucui, Wei, Lanying, Jin, Sutong, Zheng, Weisheng, Peng, Gongxin, Tang, Qihong, Zhou, Jielong, Zhang, Yingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618116/
https://www.ncbi.nlm.nih.gov/pubmed/37920819
http://dx.doi.org/10.1016/j.csbj.2023.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618116/
https://www.ncbi.nlm.nih.gov/pubmed/37920819
http://dx.doi.org/10.1016/j.csbj.2023.10.011

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