mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice

We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies an...

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Autores principales: Kim, Jae-Yong, Jeon, Kyeongseok, Park, Sang-In, Bang, Yoo-Jin, Park, Hyeong-Jun, Kwak, Hye Won, Kim, Do-Hyung, Lee, Soo-Yeon, Choi, Eun-Jin, Cho, Nam-Hyuk, Nam, Jae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618158/
https://www.ncbi.nlm.nih.gov/pubmed/37907507
http://dx.doi.org/10.1038/s41541-023-00771-2
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author Kim, Jae-Yong
Jeon, Kyeongseok
Park, Sang-In
Bang, Yoo-Jin
Park, Hyeong-Jun
Kwak, Hye Won
Kim, Do-Hyung
Lee, Soo-Yeon
Choi, Eun-Jin
Cho, Nam-Hyuk
Nam, Jae-Hwan
author_facet Kim, Jae-Yong
Jeon, Kyeongseok
Park, Sang-In
Bang, Yoo-Jin
Park, Hyeong-Jun
Kwak, Hye Won
Kim, Do-Hyung
Lee, Soo-Yeon
Choi, Eun-Jin
Cho, Nam-Hyuk
Nam, Jae-Hwan
author_sort Kim, Jae-Yong
collection PubMed
description We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.
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spelling pubmed-106181582023-11-02 mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice Kim, Jae-Yong Jeon, Kyeongseok Park, Sang-In Bang, Yoo-Jin Park, Hyeong-Jun Kwak, Hye Won Kim, Do-Hyung Lee, Soo-Yeon Choi, Eun-Jin Cho, Nam-Hyuk Nam, Jae-Hwan NPJ Vaccines Brief Communication We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate. Nature Publishing Group UK 2023-10-31 /pmc/articles/PMC10618158/ /pubmed/37907507 http://dx.doi.org/10.1038/s41541-023-00771-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Kim, Jae-Yong
Jeon, Kyeongseok
Park, Sang-In
Bang, Yoo-Jin
Park, Hyeong-Jun
Kwak, Hye Won
Kim, Do-Hyung
Lee, Soo-Yeon
Choi, Eun-Jin
Cho, Nam-Hyuk
Nam, Jae-Hwan
mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title_full mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title_fullStr mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title_full_unstemmed mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title_short mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
title_sort mrna vaccine encoding gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618158/
https://www.ncbi.nlm.nih.gov/pubmed/37907507
http://dx.doi.org/10.1038/s41541-023-00771-2
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