Synthesis of tertiary alkylphosphonate oligonucleotides through light-driven radical-polar crossover reactions

Chemical modification of nucleotides can improve the metabolic stability and target specificity of oligonucleotide therapeutics, and alkylphosphonates have been employed as charge-neutral replacements for naturally-occurring phosphodiester backbones in these compounds. However, at present, the alkyl...

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Detalles Bibliográficos
Autores principales: Ota, Kenji, Nagao, Kazunori, Hata, Dai, Sugiyama, Haruki, Segawa, Yasutomo, Tokunoh, Ryosuke, Seki, Tomohiro, Miyamoto, Naoya, Sasaki, Yusuke, Ohmiya, Hirohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618202/
https://www.ncbi.nlm.nih.gov/pubmed/37907473
http://dx.doi.org/10.1038/s41467-023-42639-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618202/
https://www.ncbi.nlm.nih.gov/pubmed/37907473
http://dx.doi.org/10.1038/s41467-023-42639-y

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