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NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Hippocampal neuronal damage may induce cognitive impairment. Neurotrophic tyrosine kinase receptor 1 (NTRK1) reportedly regulates neuronal damage, although the underlying mechanism remains unclear. The present study aimed to investigate the role of NTRK1 in mouse hippocampal neuronal damage and the...

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Detalles Bibliográficos
Autores principales: Yang, Kai, Wu, Jue, Li, Shang, Wang, Shan, Zhang, Jing, Wang, Yi-peng, Yan, You-sheng, Hu, Hua-ying, Xiong, Ming-fang, Bai, Chao-bo, Sun, Yong-qing, Chen, Wen-qi, Zeng, Yang, Yuan, Jun-liang, Yin, Cheng-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618268/
https://www.ncbi.nlm.nih.gov/pubmed/37907480
http://dx.doi.org/10.1038/s41420-023-01685-7