Site-oriented conjugation of poly(2-methacryloyloxyethyl phosphorylcholine) for enhanced brain delivery of antibody

Antibody therapeutics are limited in treating brain diseases due to poor blood-brain barrier (BBB) penetration. We have discovered that poly 2-methacryloyloxyethyl phosphorylcholine (PMPC), a biocompatible polymer, effectively facilitates BBB penetration via receptor-mediated transcytosis and have d...

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Detalles Bibliográficos
Autores principales: Ren, Jie, Jepson, Chloe E., Nealy, Sarah L., Kuhlmann, Charles J., Osuka, Satoru, Azolibe, Stella Uloma, Blucas, Madison T., Nagaoka-Kamata, Yoshiko, Kharlampieva, Eugenia, Kamata, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618420/
https://www.ncbi.nlm.nih.gov/pubmed/37920826
http://dx.doi.org/10.3389/fcell.2023.1214118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618420/
https://www.ncbi.nlm.nih.gov/pubmed/37920826
http://dx.doi.org/10.3389/fcell.2023.1214118

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