Cargando…

Site-oriented conjugation of poly(2-methacryloyloxyethyl phosphorylcholine) for enhanced brain delivery of antibody

Antibody therapeutics are limited in treating brain diseases due to poor blood-brain barrier (BBB) penetration. We have discovered that poly 2-methacryloyloxyethyl phosphorylcholine (PMPC), a biocompatible polymer, effectively facilitates BBB penetration via receptor-mediated transcytosis and have d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Jie, Jepson, Chloe E., Nealy, Sarah L., Kuhlmann, Charles J., Osuka, Satoru, Azolibe, Stella Uloma, Blucas, Madison T., Nagaoka-Kamata, Yoshiko, Kharlampieva, Eugenia, Kamata, Masakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618420/ https://www.ncbi.nlm.nih.gov/pubmed/37920826 http://dx.doi.org/10.3389/fcell.2023.1214118

Ejemplares similares

Skewed fate and hematopoiesis of CD34(+) HSPCs in umbilical cord blood amid the COVID-19 pandemic
por: Estep, Benjamin K., et al.
Publicado: (2022)

Interpolymer Complexes of Poly(methacryloyloxyethyl phosphorylcholine) and Polyacids
por: Nekrasova, Tatiana, et al.
Publicado: (2022)

A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine
por: Zhang, Ning, et al.
Publicado: (2015)

Development of Poly(2-Methacryloyloxyethyl Phosphorylcholine)-Functionalized Hydrogels for Reducing Protein and Bacterial Adsorption
por: Vales, Temmy Pegarro, et al.
Publicado: (2020)

The Influence of 2-Methacryloyloxyethyl Phosphorylcholine Polymer Materials on Orthodontic Friction and Attachment of Oral Bacteria
por: Kunimatsu, Ryo, et al.
Publicado: (2022)

Novel anti-biofouling bioactive calcium silicate-based cement containing 2-methacryloyloxyethyl phosphorylcholine
por: Kwon, Jae-Sung, et al.
Publicado: (2019)

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface
por: Ishihara, Kazuhiko, et al.
Publicado: (2021)

Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface
por: Nistorescu, Simona, et al.
Publicado: (2022)

Inhibitory effects of 2-methacryloyloxyethyl phosphorylcholine polymer on the adherence of bacteria causing upper respiratory tract infection
por: Iuchi, Hiroyuki, et al.
Publicado: (2020)

Ahmed implant coated with poly(2-methacryloyloxyethyl phosphorylcholine) inhibits foreign body reactions in rabbit eyes
por: Kee, Hyun Joo, et al.
Publicado: (2021)

Van der Waals interactions regulating the hydration of 2-methacryloyloxyethyl phosphorylcholine, the constructing monomer of biocompatible polymers
por: Takahashi, Masae, et al.
Publicado: (2022)

Novel anti-biofouling light-curable fluoride varnish containing 2-methacryloyloxyethyl phosphorylcholine to prevent enamel demineralization
por: Kwon, Jae-Sung, et al.
Publicado: (2019)

Suppressive effects of 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer on the adherence of Candida species and MRSA to acrylic denture resin
por: Fujiwara, Natsumi, et al.
Publicado: (2020)

Use of catheter with 2-methacryloyloxyethyl phosphorylcholine polymer coating is associated with long-term availability of central venous port
por: Iida, Yuuki, et al.
Publicado: (2021)

2-Methacryloyloxyethyl Phosphorylcholine Polymer Coating Inhibits Bacterial Adhesion and Biofilm Formation on a Suture: An In Vitro and In Vivo Study
por: Kaneko, Taizo, et al.
Publicado: (2020)

2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind, crossover clinical trial
por: Fujiwara, Natsumi, et al.
Publicado: (2018)

Comparative Evaluation of Pseudomonas aeruginosa Adhesion to a Poly-(2-Methacryloyloxyethyl Phosphorylcholine)-Modified Silicone Hydrogel Contact Lens
por: Harris, Valerie, et al.
Publicado: (2023)

Improvement of Uveal and Capsular Biocompatibility of Hydrophobic Acrylic Intraocular Lens by Surface Grafting with 2-Methacryloyloxyethyl Phosphorylcholine-Methacrylic Acid Copolymer
por: Tan, Xuhua, et al.
Publicado: (2017)

Synergetic Effect of 2-Methacryloyloxyethyl Phosphorylcholine and Mesoporous Bioactive Glass Nanoparticles on Antibacterial and Anti-Demineralisation Properties in Orthodontic Bonding Agents
por: Park, Se Young, et al.
Publicado: (2020)

Nanoprecipitation of polymeric nanoparticle micelles based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl methacrylate (DPA), for intracellular delivery applications
por: Salvage, Jonathan P., et al.
Publicado: (2015)

Reassessing the Role of APOBEC3G in Human Immunodeficiency Virus Type 1 Infection of Quiescent CD4+ T-Cells
por: Kamata, Masakazu, et al.
Publicado: (2009)

Therapeutic effect of intravesical administration of paclitaxel solubilized with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) in an orthotopic bladder cancer model
por: Tamura, Koetsu, et al.
Publicado: (2015)

Minimum 7-year results of cementless total hip arthroplasty with vitamin E-diffused and 2-methacryloyloxyethyl phosphorylcholine-grafted highly cross-linked polyethylene
por: Naito, Yohei, et al.
Publicado: (2023)

Self-assemblies of γ-CDs with pentablock copolymers PMA-PPO-PEO-PPO-PMA and endcapping via atom transfer radical polymerization of 2-methacryloyloxyethyl phosphorylcholine
por: Lin, Jing, et al.
Publicado: (2015)

Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs
por: Kamata, Masakazu, et al.
Publicado: (2010)

High risk of elevated metal concentrations with 9/10-mm stem trunnions and highly cross-linked polyethylene grafted with poly(2-methacryloyloxyethyl phosphorylcholine) in total hip arthroplasty
por: Kobayashi, Kyosuke, et al.
Publicado: (2023)

Modification of a polyethersulfone membrane with a block copolymer brush of poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate) and a branched polypeptide chain of Arg–Glu–Asp–Val
por: Niu, Xiaoqin, et al.
Publicado: (2019)

Targeting Phosphorylcholine in Established Atherosclerosis?
por: Tsiantoulas, Dimitrios
Publicado: (2020)

Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism
por: Yui, Satoru, et al.
Publicado: (2014)

CLONAL NATURE OF THE IMMUNE RESPONSE TO PHOSPHORYLCHOLINE : I. SPECIFICITY, CLASS, AND IDIOTYPE OF PHOSPHORYLCHOLINE-BINDING RECEPTORS ON LYMPHOID CELLS
por: Claflin, J. Latham, et al.
Publicado: (1974)

Effects of copolymer component on the properties of phosphorylcholine micelles
por: Wu, Zhengzhong, et al.
Publicado: (2017)

Efficient derivation of chimeric-antigen receptor-modified T(SCM) cells
por: Kranz, Emiko, et al.
Publicado: (2022)

Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modification
por: Zhang, Yuan, et al.
Publicado: (2023)

Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa
por: Domenech, Carlos Eduardo, et al.
Publicado: (2011)

Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae
por: Clark, Sarah E., et al.
Publicado: (2012)

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases
por: Frostegård, Johan
Publicado: (2023)

Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models
por: Baghdasaryan, Ani, et al.
Publicado: (2022)

Insulin‐like growth factor‐1 signaling is responsible for cathepsin G‐induced aggregation of breast cancer MCF‐7 cells
por: Morimoto‐Kamata, Riyo, et al.
Publicado: (2017)

Expression of phosphorylcholine-specific B cells during murine development
por: Sigal, NH, et al.
Publicado: (1977)

The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_0ernjlmcp1hu9cvfso30k26lco