Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease

Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed a screening platform, ATRIVIEW(®), for molecules that activate neuronal differentiation of adult mouse NSCs. The most potent hit from an FDA-approved drug library was SNR1611 (tramet...

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Detalles Bibliográficos
Autores principales: Kim, Mi-Yeon, Kim, Mi Jeong, Lee, Changyeob, Lee, Juwon, Kim, Sang Seong, Hong, Sungho, Kim, Hyoung Tae, Seo, Jinsoo, Yoon, Ki-Jun, Han, Sungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618442/
https://www.ncbi.nlm.nih.gov/pubmed/37779138
http://dx.doi.org/10.1038/s12276-023-01073-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618442/
https://www.ncbi.nlm.nih.gov/pubmed/37779138
http://dx.doi.org/10.1038/s12276-023-01073-2

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