Cargando…

Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease

Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed a screening platform, ATRIVIEW(®), for molecules that activate neuronal differentiation of adult mouse NSCs. The most potent hit from an FDA-approved drug library was SNR1611 (tramet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Mi-Yeon, Kim, Mi Jeong, Lee, Changyeob, Lee, Juwon, Kim, Sang Seong, Hong, Sungho, Kim, Hyoung Tae, Seo, Jinsoo, Yoon, Ki-Jun, Han, Sungho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618442/ https://www.ncbi.nlm.nih.gov/pubmed/37779138 http://dx.doi.org/10.1038/s12276-023-01073-2

Ejemplares similares

MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease
por: Chun, Yoon Sun, et al.
Publicado: (2022)

Neurogenesis Makes a Crucial Contribution to the Neuropathology of Alzheimer’s Disease
por: Young, John K.
Publicado: (2020)

On privacy enhancement using u-indistinguishability to COVID-19 contact tracing approach in Korea
por: Kim, Hyoung Joong, et al.
Publicado: (2021)

Impact of Enforcement of the Act to Improve Training Conditions and the Status of Medical Residents in Emergency Abdominal Surgery
por: Lee, Sungho, et al.
Publicado: (2022)

Preserved neurogenesis in non-demented individuals with AD neuropathology
por: Briley, David, et al.
Publicado: (2016)

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
por: Wen, Lei, et al.
Publicado: (2011)

The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
por: Wegiel, Jerzy, et al.
Publicado: (2010)

Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model
por: Jeong, Chang Hyun, et al.
Publicado: (2014)

Functional Group-Dependent Induction of Astrocytogenesis and Neurogenesis by Flavone Derivatives
por: Lee, Ha-Rim, et al.
Publicado: (2019)

Small Infrared Target Detection by Region-Adaptive Clutter Rejection for Sea-Based Infrared Search and Track
por: Kim, Sungho, et al.
Publicado: (2014)

Relationship between adult subventricular neurogenesis and Alzheimer’s disease: Pathologic roles and therapeutic implications
por: Kim, Hyeon Soo, et al.
Publicado: (2022)

Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer’s Disease
por: Lee, Danbi, et al.
Publicado: (2022)

Neuropathologic and Clinical Features of Human Medial Temporal Lobe Epilepsy
por: Bae, Eun-Kee, et al.
Publicado: (2010)

Treadmill exercise alleviates prenatal noise stress-induced impairment of spatial learning ability through enhancing hippocampal neurogenesis in rat pups
por: Kim, Tae-Woon, et al.
Publicado: (2013)

Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice
por: Park, Sang-Seo, et al.
Publicado: (2021)

The neuropathological diagnosis of Alzheimer’s disease
por: DeTure, Michael A., et al.
Publicado: (2019)

Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia
por: Kim, Yu Ri, et al.
Publicado: (2014)

Inverted polymer fullerene solar cells exceeding 10% efficiency with poly(2-ethyl-2-oxazoline) nanodots on electron-collecting buffer layers
por: Nam, Sungho, et al.
Publicado: (2015)

A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010
por: Kim, Shin Hye, et al.
Publicado: (2015)

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice
por: Fiorentini, Anna, et al.
Publicado: (2010)

Adult hippocampal neurogenesis and its impairment in Alzheimer’s disease
por: Kim, Thomas A., et al.
Publicado: (2022)

High-Speed Incoming Infrared Target Detection by Fusion of Spatial and Temporal Detectors
por: Kim, Sungho
Publicado: (2015)

Unsupervised Spectral-Spatial Feature Selection-Based Camouflaged Object Detection Using VNIR Hyperspectral Camera
por: Kim, Sungho
Publicado: (2015)

Sea-Based Infrared Scene Interpretation by Background Type Classification and Coastal Region Detection for Small Target Detection
por: Kim, Sungho
Publicado: (2015)

Analysis of Infrared Signature Variation and Robust Filter-Based Supersonic Target Detection
por: Kim, Sungho, et al.
Publicado: (2014)

Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice
por: Seong, Kyung-Joo, et al.
Publicado: (2016)

Development and Validation of an Arterial Pressure-Based Cardiac Output Algorithm Using a Convolutional Neural Network: Retrospective Study Based on Prospective Registry Data
por: Yang, Hyun-Lim, et al.
Publicado: (2021)

Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway
por: Yao, Yuyuan, et al.
Publicado: (2022)

Development of IoT-Based Particulate Matter Monitoring System for Construction Sites
por: Kim, Hyunsik, et al.
Publicado: (2021)

Genomics: New Light on Alzheimer’s Disease Research
por: Jung, Yeong Ju, et al.
Publicado: (2018)

Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development
por: Rabinovici, Gil D., et al.
Publicado: (2016)

Eco Assist Techniques through Real-time Monitoring of BEV Energy Usage Efficiency
por: Kim, Younsun, et al.
Publicado: (2015)

Effects of Autonomous Sensory Meridian Response on the Functional Connectivity as Measured by Functional Magnetic Resonance Imaging
por: Lee, Seonjin, et al.
Publicado: (2020)

An Adaptive Spreading Factor Selection Scheme for a Single Channel LoRa Modem
por: Kim, Seungku, et al.
Publicado: (2020)

Antitumor Activity of Combination Therapy with Metformin and Trametinib in Non-Small Cell Lung Cancer Cells
por: Ko, Eunjeong, et al.
Publicado: (2020)

Midwave FTIR-Based Remote Surface Temperature Estimation Using a Deep Convolutional Neural Network in a Dynamic Weather Environment
por: Kim, Sungho, et al.
Publicado: (2018)

Epigenetic Modifications in Alzheimer’s Neuropathology and Therapeutics
por: Esposito, Michelle, et al.
Publicado: (2019)

Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
por: Doher, Nicholas, et al.
Publicado: (2023)

Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development
por: Paez-Gonzalez, Patricia, et al.
Publicado: (2023)

Can We Reboot the Role of Intraperitoneal Chemotherapy in the Treatment for Gastric Cancer with Peritoneal Carcinomatosis?: A Retrospective Cohort Study Regarding Minimally Invasive Surgery Conjoined with Intraperitoneal plus Systemic Chemotherapy
por: Kim, Sungho, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2dur4e5ba4e71fno7e2lajis6u