Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53

Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2 (mPGES-2) is a PGE(2) synthase but can metabolize PGH(2) to malondialdehyde by forming a complex with heme. However, the role and mechanism of action of m...

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Detalles Bibliográficos
Autores principales: Zhong, Dandan, Quan, Lingling, Hao, Chang, Chen, Jingshuo, Qiao, Ranran, Lin, Tengfei, Ying, Changjiang, Sun, Dong, Jia, Zhanjun, Sun, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618563/
https://www.ncbi.nlm.nih.gov/pubmed/37907523
http://dx.doi.org/10.1038/s41419-023-06236-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618563/
https://www.ncbi.nlm.nih.gov/pubmed/37907523
http://dx.doi.org/10.1038/s41419-023-06236-7

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