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Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53
Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2 (mPGES-2) is a PGE(2) synthase but can metabolize PGH(2) to malondialdehyde by forming a complex with heme. However, the role and mechanism of action of m...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618563/ https://www.ncbi.nlm.nih.gov/pubmed/37907523 http://dx.doi.org/10.1038/s41419-023-06236-7 |