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Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies

PURPOSE: Target-dependent TCB activity can result in the strong and systemic release of cytokines that may develop into cytokine release syndrome (CRS), highlighting the need to understand and prevent this complex clinical syndrome. EXPERIMENTAL DESIGN: We explored the cellular and molecular players...

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Detalles Bibliográficos
Autores principales: Leclercq-Cohen, Gabrielle, Steinhoff, Nathalie, Albertí Servera, Llucia, Nassiri, Sina, Danilin, Sabrina, Piccione, Emily, Yángüez, Emilio, Hüsser, Tamara, Herter, Sylvia, Schmeing, Stephan, Gerber, Petra, Schwalie, Petra, Sam, Johannes, Briner, Stefanie, Jenni, Sylvia, Bianchi, Roberta, Biehl, Marlene, Cremasco, Floriana, Apostolopoulou, Katerina, Haegel, Hélène, Klein, Christian, Umaña, Pablo, Bacac, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618647/
https://www.ncbi.nlm.nih.gov/pubmed/37379429
http://dx.doi.org/10.1158/1078-0432.CCR-22-3667