Cargando…

Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer

Long noncoding RNAs (lncRNA) play an important role in gene regulation in both normal tissues and cancer. Targeting lncRNAs is a promising therapeutic approach that has become feasible through the development of gapmer antisense oligonucleotides (ASO). Metastasis-associated lung adenocarcinoma trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adewunmi, Oluwatoyosi, Shen, Yichao, Zhang, Xiang H.-F., Rosen, Jeffrey M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618655/ https://www.ncbi.nlm.nih.gov/pubmed/37603945 http://dx.doi.org/10.1158/2326-6066.CIR-23-0045

Ejemplares similares

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer
por: Mekky, Radwa Y., et al.
Publicado: (2023)

LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer
por: Zhou, Qinfeng, et al.
Publicado: (2018)

JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1
por: Liu, Junping, et al.
Publicado: (2022)

A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis
por: Hu, Yu, et al.
Publicado: (2023)

Regulatory Networks of LncRNA MALAT-1 in Cancer
por: Fu, Shijian, et al.
Publicado: (2020)

Finely tuned conformational dynamics regulate the protective function of the lncRNA MALAT1 triple helix
por: Ageeli, Abeer A, et al.
Publicado: (2019)

Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients
por: Zheng, Miao, et al.
Publicado: (2020)

Effect of LncRNA-MALAT1 on mineralization of dental pulp cells in a high-glucose microenvironment
por: Li, Xinzhu, et al.
Publicado: (2022)

LncRNA MALAT1 Facilitates Ovarian Cancer Progression through Promoting Chemoresistance and Invasiveness in the Tumor Microenvironment
por: Mao, Tsui-Lien, et al.
Publicado: (2021)

Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy
por: Shaath, Hibah, et al.
Publicado: (2021)

Epigenetic regulation of cutaneous T-cell lymphoma is mediated by dysregulated lncRNA MALAT1 through modulation of tumor microenvironment
por: Guo, Wei, et al.
Publicado: (2022)

Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of β-catenin
por: Zhang, Zhi-Chang, et al.
Publicado: (2018)

Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings
por: Ahmadi, Abdolrahim, et al.
Publicado: (2018)

The role of LncRNA MALAT-1 and MiRNA-9 in Psoriasis
por: Elamir, Azza M., et al.
Publicado: (2021)

Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance
por: Hou, Junhui, et al.
Publicado: (2023)

LncRNA MALAT1 knockdown inhibits the development of choroidal neovascularization
por: Zhang, Xiaoli, et al.
Publicado: (2023)

An HNSCC syngeneic mouse model for tumor immunology research and preclinical evaluation
por: Fu, You, et al.
Publicado: (2020)

LncRNA expression profile during autophagy and Malat1 function in macrophages
por: Ma, Zhanbing, et al.
Publicado: (2019)

The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis
por: Xia, Hongwei, et al.
Publicado: (2016)

EPC‐derived exosomes promote osteoclastogenesis through LncRNA‐MALAT1
por: Cui, Yigong, et al.
Publicado: (2019)

The Role of the lncRNA MALAT1 in Neuroprotection against Hypoxic/Ischemic Injury
por: Wang, Liping, et al.
Publicado: (2022)

Role of lncRNA MALAT1 in UVA-induced corneal endothelial senescence
por: Qiao, Yujie, et al.
Publicado: (2023)

LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
por: Hao, Longhui, et al.
Publicado: (2023)

LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer
por: Wang, Dejie, et al.
Publicado: (2015)

Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus
por: Liu, J-Y, et al.
Publicado: (2014)

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
por: Arun, Gayatri, et al.
Publicado: (2016)

Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer
por: Zhao, Kexin, et al.
Publicado: (2018)

The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration
por: Li, Cuicui, et al.
Publicado: (2017)

LncRNA MALAT1 Modulates TGF-β1-Induced EMT in Keratinocyte
por: Zhang, Liping, et al.
Publicado: (2021)

lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell
por: Huang, Yongye, et al.
Publicado: (2021)

Alternative splicing modulation mediated by G-quadruplex structures in MALAT1 lncRNA
por: Ghosh, Arpita, et al.
Publicado: (2021)

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis
por: Wang, Yirong, et al.
Publicado: (2019)

The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
por: Zhang, Haomeng, et al.
Publicado: (2021)

Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA
por: Zong, Xinying, et al.
Publicado: (2016)

LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2
por: Wang, Xin, et al.
Publicado: (2016)

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke
por: Wang, Yan, et al.
Publicado: (2020)

Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1
por: Jiang, Xia, et al.
Publicado: (2020)

An Integrated Transcriptomics and Proteomics Analysis Implicates lncRNA MALAT1 in the Regulation of Lipid Metabolism
por: Wang, Hao, et al.
Publicado: (2021)

Associations between LncRNA MALAT1 Polymorphisms and Lymph Node Metastasis in Prostate Cancer
por: Hu, Ju-Chuan, et al.
Publicado: (2021)

Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS
por: Tu, Mixue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rt3ng1bg83g0tkdhcctcjcv3sj