Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments

INTRODUCTION: Immuno-oncology (IO) research relies heavily on murine syngeneic tumor models. However, whilst the average age for a cancer diagnosis is 60 years or older, for practical purposes the majority of preclinical studies are conducted in young mice, despite the fact that ageing has been show...

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Detalles Bibliográficos
Autores principales: Sitnikova, Suzanne I., Walker, Jennifer A., Prickett, Laura B., Morrow, Michelle, Valge-Archer, Viia E., Robinson, Matthew J., Wilkinson, Robert W., Dovedi, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618668/
https://www.ncbi.nlm.nih.gov/pubmed/37920465
http://dx.doi.org/10.3389/fimmu.2023.1258291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618668/
https://www.ncbi.nlm.nih.gov/pubmed/37920465
http://dx.doi.org/10.3389/fimmu.2023.1258291

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