FGF/FGFR genomic amplification as a predictive biomarker for immune checkpoint blockade resistance: a short report

A novel crosstalk between immunogenic and oncometabolic pathways triggered by T cell-released interferon-gamma (IFN-ɣ) has been recently identified. This IFN-ɣ-pyruvate kinase M2-β-catenin axis relies on fibroblast growth factor 2 (FGF2) signaling in tumor cells and leads to hyperprogressive disease...

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Detalles Bibliográficos
Autores principales: Roussot, Nicolas, Lecuelle, Julie, Dalens, Lorraine, Truntzer, Caroline, Ghiringhelli, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618988/
https://www.ncbi.nlm.nih.gov/pubmed/37890888
http://dx.doi.org/10.1136/jitc-2023-007763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618988/
https://www.ncbi.nlm.nih.gov/pubmed/37890888
http://dx.doi.org/10.1136/jitc-2023-007763

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