Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor models

BACKGROUND: CD3 bispecific antibodies (CD3-bsAbs) require binding of both a tumor-associated surface antigen and CD3 for their immunotherapeutic effect. Their efficacy is, therefore, influenced by the tumor uptake and the extracellular dose. To optimize their currently limited efficacy in solid tumo...

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Detalles Bibliográficos
Autores principales: Sandker, Gerwin Gerhard Wemke, Middelburg, Jim, Wilbrink, Evienne, Molkenboer-Kuenen, Janneke, Aarntzen, Erik, van Hall, Thorbald, Heskamp, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619024/
https://www.ncbi.nlm.nih.gov/pubmed/37899133
http://dx.doi.org/10.1136/jitc-2023-007596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619024/
https://www.ncbi.nlm.nih.gov/pubmed/37899133
http://dx.doi.org/10.1136/jitc-2023-007596

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