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Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor models
BACKGROUND: CD3 bispecific antibodies (CD3-bsAbs) require binding of both a tumor-associated surface antigen and CD3 for their immunotherapeutic effect. Their efficacy is, therefore, influenced by the tumor uptake and the extracellular dose. To optimize their currently limited efficacy in solid tumo...
Autores principales: | Sandker, Gerwin Gerhard Wemke, Middelburg, Jim, Wilbrink, Evienne, Molkenboer-Kuenen, Janneke, Aarntzen, Erik, van Hall, Thorbald, Heskamp, Sandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619024/ https://www.ncbi.nlm.nih.gov/pubmed/37899133 http://dx.doi.org/10.1136/jitc-2023-007596 |
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