A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening

Yes-associated protein (YAP), the master transcriptional effector downstream of the Hippo pathway, regulates essential cell growth and regenerative processes in animals. However, the activation of YAP observed in cancers drives cellular proliferation, metastasis, chemoresistance, and immune suppress...

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Detalles Bibliográficos
Autores principales: Nutsch, Kayla, Song, Lirui, Chen, Emily, Hull, Mitchell, Chatterjee, Arnab K., Chen, Jian Jeffery, Bollong, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619132/
https://www.ncbi.nlm.nih.gov/pubmed/37920398
http://dx.doi.org/10.1039/d3cb00044c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619132/
https://www.ncbi.nlm.nih.gov/pubmed/37920398
http://dx.doi.org/10.1039/d3cb00044c

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