Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors

Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium Pseudomonas aeruginosa synthesises copious quantities of the virulence factor and exopolysaccharide alginate. The enzyme guanosine diphosphate mannose dehydrogenase (GMD) catalyses the rate-limit...

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Detalles Bibliográficos
Autores principales: Dolan, Jonathan P., Ahmadipour, Sanaz, Wahart, Alice J. C., Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A., Skidmore, Mark A., Volcho, Konstantin P., Reynisson, Jóhannes, Field, Robert A., Miller, Gavin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619135/
https://www.ncbi.nlm.nih.gov/pubmed/37920392
http://dx.doi.org/10.1039/d3cb00126a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619135/
https://www.ncbi.nlm.nih.gov/pubmed/37920392
http://dx.doi.org/10.1039/d3cb00126a

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