Cargando…

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors

Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium Pseudomonas aeruginosa synthesises copious quantities of the virulence factor and exopolysaccharide alginate. The enzyme guanosine diphosphate mannose dehydrogenase (GMD) catalyses the rate-limit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolan, Jonathan P., Ahmadipour, Sanaz, Wahart, Alice J. C., Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A., Skidmore, Mark A., Volcho, Konstantin P., Reynisson, Jóhannes, Field, Robert A., Miller, Gavin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619135/ https://www.ncbi.nlm.nih.gov/pubmed/37920392 http://dx.doi.org/10.1039/d3cb00126a

Ejemplares similares

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase
por: Ahmadipour, Sanaz, et al.
Publicado: (2022)

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target
por: Eurtivong, Chatchakorn, et al.
Publicado: (2023)

Comparative characterization of two GDP-mannose dehydrogenase genes from Saccharina japonica (Laminariales, Phaeophyceae)
por: Zhang, Pengyan, et al.
Publicado: (2016)

Molecular docking study of lamellarin analogues and identification of potential inhibitors of HIV-1 integrase strand transfer complex by virtual screening
por: Eurtivong, Chatchakorn, et al.
Publicado: (2019)

GDP-Mannose Pyrophosphorylase B (GMPPB)-Related Disorders
por: Chompoopong, Pitcha, et al.
Publicado: (2023)

Assessing the Potential of Gallic Acid and Methyl Gallate to Enhance the Efficacy of β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus by Targeting β-Lactamase: In Silico and In Vitro Studies
por: Jiamboonsri, Pimsumon, et al.
Publicado: (2023)

Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase
por: Li, Hang, et al.
Publicado: (2022)

Characterization of the GDP-D-Mannose Biosynthesis Pathway in Coxiella burnetii: The Initial Steps for GDP-β-D-Virenose Biosynthesis
por: Narasaki, Craig T., et al.
Publicado: (2011)

Mutation of GDP-Mannose-4,6-Dehydratase in Colorectal Cancer Metastasis
por: Nakayama, Kotarosumitomo, et al.
Publicado: (2013)

Characterization of the First Bacterial and Thermostable GDP-Mannose 3,5-Epimerase
por: Gevaert, Ophelia, et al.
Publicado: (2019)

Cell-free enzymatic synthesis of GDP-l-fucose from mannose
por: Wang, Weiyang, et al.
Publicado: (2019)

Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities
por: Levaique, Hélène, et al.
Publicado: (2021)

Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose
por: Yi, Yuqi, et al.
Publicado: (2021)

Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum
por: Premageetha, Gowtham Thambra Rajan, et al.
Publicado: (2023)

Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica
por: Zou, Lu, et al.
Publicado: (2012)

Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads
por: Mao, Wei, et al.
Publicado: (2017)

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase
por: Pfeiffer, Martin, et al.
Publicado: (2019)

GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis
por: Pomel, Sébastien, et al.
Publicado: (2019)

GDP-Mannose 3,5-Epimerase: A View on Structure, Mechanism, and Industrial Potential
por: Beerens, Koen, et al.
Publicado: (2022)

Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production
por: Fu, Cong, et al.
Publicado: (2023)

Disruption of the GDP-mannose synthesis pathway in Streptomyces coelicolor results in antibiotic hyper-susceptible phenotypes
por: Howlett, Robert, et al.
Publicado: (2018)

Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1
por: Zhang, Chi, et al.
Publicado: (2022)

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei
por: Kuettel, Sabine, et al.
Publicado: (2012)

Prospects for anti-Candida therapy through targeting the cell wall: A mini-review
por: Ahmadipour, Sanaz, et al.
Publicado: (2021)

GDP-D-mannose epimerase regulates male gametophyte development, plant growth and leaf senescence in Arabidopsis
por: Qi, Tiancong, et al.
Publicado: (2017)

One pot synthesis of GDP‐mannose by a multi‐enzyme cascade for enzymatic assembly of lipid‐linked oligosaccharides
por: Rexer, Thomas F.T., et al.
Publicado: (2017)

Molecular Evolution of GDP-D-Mannose Epimerase (GME), a Key Gene in Plant Ascorbic Acid Biosynthesis
por: Tao, Junjie, et al.
Publicado: (2018)

Minor Impact of A258D Mutation on Biochemical and Enzymatic Properties of Leishmania infantum GDP-Mannose Pyrophosphorylase
por: Mao, Wei, et al.
Publicado: (2022)

A mutation in GDP-mannose pyrophosphorylase causes conditional hypersensitivity to ammonium, resulting in Arabidopsis root growth inhibition, altered ammonium metabolism, and hormone homeostasis
por: Barth, Carina, et al.
Publicado: (2010)

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening
por: Sari, Suat, et al.
Publicado: (2019)

Biochemical and Functional Studies on the Burkholderia cepacia Complex bceN Gene, Encoding a GDP-D-Mannose 4,6-Dehydratase
por: Sousa, Sílvia A., et al.
Publicado: (2013)

Osteoradionecrosis GDP survey
por: Shah, A., et al.
Publicado: (2020)

Two tomato GDP-D-mannose epimerase isoforms involved in ascorbate biosynthesis play specific roles in cell wall biosynthesis and development
por: Mounet-Gilbert, Louise, et al.
Publicado: (2016)

AgGMP encoding GDP-D-mannose pyrophosphorylase from celery enhanced the accumulation of ascorbic acid and resistance to drought stress in Arabidopsis
por: Liu, Yan-Hua, et al.
Publicado: (2022)

The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice
por: Varinthra, Peeraporn, et al.
Publicado: (2021)

Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase
por: de Andrade, Peterson, et al.
Publicado: (2022)

Identification and characterization of Arabidopsis AtNUDX9 as a GDP-d-mannose pyrophosphohydrolase: its involvement in root growth inhibition in response to ammonium
por: Tanaka, Hiroyuki, et al.
Publicado: (2015)

Nowcasting Japan’s GDP
por: Hayashi, Fumio, et al.
Publicado: (2022)

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases
por: Lygidakis, Antonios, et al.
Publicado: (2016)

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases
por: Lygidakis, Antonios, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kgaefcsqij5qiop7g22v6ic0rm