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Protein conformational ensembles in function: roles and mechanisms

The sequence-structure-function paradigm has dominated twentieth century molecular biology. The paradigm tacitly stipulated that for each sequence there exists a single, well-organized protein structure. Yet, to sustain cell life, function requires (i) that there be more than a single structure, (ii...

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Detalles Bibliográficos
Autores principales: Nussinov, Ruth, Liu, Yonglan, Zhang, Wengang, Jang, Hyunbum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619138/
https://www.ncbi.nlm.nih.gov/pubmed/37920394
http://dx.doi.org/10.1039/d3cb00114h