The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation

BACKGROUND: Disruption of the extracellular matrix at the blood–brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) proteoglycans, can be prevented by treatment with HS-mimetics through their abi...

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Detalles Bibliográficos
Autores principales: Peck, Tessa, Davis, Connor, Lenihan-Geels, Georgia, Griffiths, Maddie, Spijkers-Shaw, Sam, Zubkova, Olga V., La Flamme, Anne Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619265/
https://www.ncbi.nlm.nih.gov/pubmed/37915090
http://dx.doi.org/10.1186/s12974-023-02925-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619265/
https://www.ncbi.nlm.nih.gov/pubmed/37915090
http://dx.doi.org/10.1186/s12974-023-02925-4

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