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The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation
BACKGROUND: Disruption of the extracellular matrix at the blood–brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) proteoglycans, can be prevented by treatment with HS-mimetics through their abi...
Autores principales: | Peck, Tessa, Davis, Connor, Lenihan-Geels, Georgia, Griffiths, Maddie, Spijkers-Shaw, Sam, Zubkova, Olga V., La Flamme, Anne Camille |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619265/ https://www.ncbi.nlm.nih.gov/pubmed/37915090 http://dx.doi.org/10.1186/s12974-023-02925-4 |
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