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Carbamazepine regulates USP10 through miR-20a-5p to affect the deubiquitination of SKP2 and inhibit osteogenic differentiation

BACKGROUND: Antiepileptic drugs (AEDs) harm bone health and are significantly associated with osteoporosis development. In this study, we aimed to explore the mechanisms involved in carbamazepine (CBZ) and microRNA (miR)-20a-5p/ubiquitin-specific peptidase 10 (USP10)/S-phase kinase-associated protei...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Liu, Ziye, Niu, Dawei, Li, Haobo, Han, Yaguang, Peng, Jinhui, Qian, Qirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619296/
https://www.ncbi.nlm.nih.gov/pubmed/37915040
http://dx.doi.org/10.1186/s13018-023-04169-7