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Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum

Haloalkane dehalogenases (HLDs) are a family of α/β-hydrolase fold enzymes that employ S(N)2 nucleophilic substitution to cleave the carbon–halogen bond in diverse chemical structures, the biological role of which is still poorly understood. Atomic-level knowledge of both the inner organization and...

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Detalles Bibliográficos
Autores principales: Snajdarova, Karolina, Marques, Sérgio M., Damborsky, Jiri, Bednar, David, Marek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619424/
https://www.ncbi.nlm.nih.gov/pubmed/37860958
http://dx.doi.org/10.1107/S2059798323006642