Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression triggers pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) to induc...

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Detalles Bibliográficos
Autores principales: Pethő, Zoltán, Najder, Karolina, Beel, Stephanie, Fels, Benedikt, Neumann, Ilka, Schimmelpfennig, Sandra, Sargin, Sarah, Wolters, Maria, Grantins, Klavs, Wardelmann, Eva, Mitkovski, Miso, Oeckinghaus, Andrea, Schwab, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619433/
https://www.ncbi.nlm.nih.gov/pubmed/37643024
http://dx.doi.org/10.1172/jci.insight.170928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619433/
https://www.ncbi.nlm.nih.gov/pubmed/37643024
http://dx.doi.org/10.1172/jci.insight.170928

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