RhoA vesicle trafficking–mediated transglutaminase 2 membrane translocation promotes IgA1 mesangial deposition in IgA nephropathy

Transglutaminase 2 (TGase2) has been shown to contribute to the mesangial IgA1 deposition in a humanized mouse model of IgA nephropathy (IgAN), but the mechanism is not fully understood. In this study, we found that inhibition of TGase2 activity could dramatically decrease the amount of polymeric Ig...

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Detalles Bibliográficos
Autores principales: Zhong, Zhong, Li, Zhijian, Li, Yanjie, Jiang, Lanping, Kong, Qingyu, Chen, Wei, Feng, Shaozhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619437/
https://www.ncbi.nlm.nih.gov/pubmed/37811653
http://dx.doi.org/10.1172/jci.insight.160374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619437/
https://www.ncbi.nlm.nih.gov/pubmed/37811653
http://dx.doi.org/10.1172/jci.insight.160374

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