PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia

Overexpression of phosphatases of regenerating liver 2 (PRL2), detected in numerous diverse cancers, is often associated with increased severity and poor patient prognosis. PRL2-catalyzed tyrosine dephosphorylation of the tumor suppressor PTEN results in increased PTEN degradation and has been ident...

Descripción completa

Detalles Bibliográficos
Autores principales: Carlock, Colin, Bai, Yunpeng, Paige-Hood, Allison, Li, Qinglin, Nguele Meke, Frederick, Zhang, Zhong-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
https://www.ncbi.nlm.nih.gov/pubmed/37665633
http://dx.doi.org/10.1172/jci.insight.170065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
https://www.ncbi.nlm.nih.gov/pubmed/37665633
http://dx.doi.org/10.1172/jci.insight.170065

Ejemplares similares