Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection

Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding CARs. However, these models could underreprese...

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Detalles Bibliográficos
Autores principales: Rosado-Sánchez, Isaac, Haque, Manjurul, Salim, Kevin, Speck, Madeleine, Fung, Vivian C.W., Boardman, Dominic A., Mojibian, Majid, Raimondi, Giorgio, Levings, Megan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619441/
https://www.ncbi.nlm.nih.gov/pubmed/37669115
http://dx.doi.org/10.1172/jci.insight.167215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619441/
https://www.ncbi.nlm.nih.gov/pubmed/37669115
http://dx.doi.org/10.1172/jci.insight.167215

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