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Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3(+) memory B cells and plasmablasts

Many autoimmune diseases (AIDs) are characterized by the persistence of autoreactive B cell responses, which have been directly implicated in disease pathogenesis. How and why these cells are generated or how they are maintained for years is largely unknown. Rheumatoid arthritis (RA) is among the mo...

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Detalles Bibliográficos
Autores principales: Reijm, Sanne, Kwekkeboom, Joanneke C., Blomberg, Nienke J., Suurmond, Jolien, van der Woude, Diane, Toes, René E.M., Scherer, Hans U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619489/
https://www.ncbi.nlm.nih.gov/pubmed/37725442
http://dx.doi.org/10.1172/jci.insight.172006