Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis

Cellular senescence and biliary fibrosis are prototypical features of obliterative cholangiopathies, such as primary sclerosing cholangitis (PSC). Telomere dysfunction can lead to senescence either through telomere erosion or damaged telomeres. Our goal was to investigate a mechanistic relationship...

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Detalles Bibliográficos
Autores principales: Jalan-Sakrikar, Nidhi, Anwar, Abid, Yaqoob, Usman, Gan, Can, Lagnado, Anthony B., Wixom, Alexander Q., Jurk, Diana, Huebert, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619490/
https://www.ncbi.nlm.nih.gov/pubmed/37707950
http://dx.doi.org/10.1172/jci.insight.170320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619490/
https://www.ncbi.nlm.nih.gov/pubmed/37707950
http://dx.doi.org/10.1172/jci.insight.170320

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