An aging-susceptible circadian rhythm controls cutaneous antiviral immunity

Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced levels of antiviral proteins (AVPs) and circadian regulators, including Bmal1 and Clock. Bmal1 and Clock were found t...

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Detalles Bibliográficos
Autores principales: Kirchner, Stephen J., Lei, Vivian, Kim, Paul T., Patel, Meera, Shannon, Jessica L., Corcoran, David, Hughes, Dalton, Waters, Diana K., Dzirasa, Kafui, Erdmann, Detlev, Coers, Jörn, MacLeod, Amanda S., Zhang, Jennifer Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619492/
https://www.ncbi.nlm.nih.gov/pubmed/37725438
http://dx.doi.org/10.1172/jci.insight.171548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619492/
https://www.ncbi.nlm.nih.gov/pubmed/37725438
http://dx.doi.org/10.1172/jci.insight.171548

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