The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas

Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse progression in most carcinomas. Using samples from patients with CRC, mouse mo...

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Detalles Bibliográficos
Autores principales: Sánchez-Tilló, Ester, Pedrosa, Leire, Vila, Ingrid, Chen, Yongxu, Győrffy, Balázs, Sánchez-Moral, Lidia, Siles, Laura, Lozano, Juan J., Esteve-Codina, Anna, Darling, Douglas S., Cuatrecasas, Miriam, Castells, Antoni, Maurel, Joan, Postigo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619495/
https://www.ncbi.nlm.nih.gov/pubmed/37870961
http://dx.doi.org/10.1172/jci.insight.164629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619495/
https://www.ncbi.nlm.nih.gov/pubmed/37870961
http://dx.doi.org/10.1172/jci.insight.164629

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