Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmp(gt/gt) mouse model of slowly progressing liver fibrosis

Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been insufficiently characterized in liver disease. The Glmp(gt/gt) mouse lacks expression...

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Detalles Bibliográficos
Autores principales: Antwi, Milton Boaheng, Dumitriu, Gianina, Simón-Santamaria, Jaione, Romano, Javier Sánchez, Li, Ruomei, Smedsrød, Bård, Vik, Anders, Eskild, Winnie, Sørensen, Karen Kristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619817/
https://www.ncbi.nlm.nih.gov/pubmed/37910485
http://dx.doi.org/10.1371/journal.pone.0293526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619817/
https://www.ncbi.nlm.nih.gov/pubmed/37910485
http://dx.doi.org/10.1371/journal.pone.0293526

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