Cargando…

Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition

The amygdala processes positive and negative valence and contributes to addiction, but the cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of single-nucleus gene expression and chromatin accessibility in the amygdala of outbred rats with high and low cocaine a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jessica L., de Guglielmo, Giordano, Ho, Aaron J., Kallupi, Marsida, Pokhrel, Narayan, Li, Hai-Ri, Chitre, Apurva S., Munro, Daniel, Mohammadi, Pejman, Carrette, Lieselot L. G., George, Olivier, Palmer, Abraham A., McVicker, Graham, Telese, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620093/ https://www.ncbi.nlm.nih.gov/pubmed/37798411 http://dx.doi.org/10.1038/s41593-023-01452-y

Ejemplares similares

Author Correction: Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
por: Zhou, Jessica L., et al.
Publicado: (2023)

The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction
por: Carrette, Lieselot L. G., et al.
Publicado: (2021)

Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway
por: Kumaresan, Vidhya, et al.
Publicado: (2023)

MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala
por: Kallupi, Marsida, et al.
Publicado: (2014)

The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats
por: Munro, Daniel, et al.
Publicado: (2022)

Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats
por: Peterson, Veronica L., et al.
Publicado: (2020)

Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats
por: Carrette, Lieselot L. G., et al.
Publicado: (2022)

Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood
por: Kononoff, Jenni, et al.
Publicado: (2018)

Editorial: The Role of Neuropeptides in Drug Addiction and Other Psychiatric Disorders
por: Lutfy, Kabirullah, et al.
Publicado: (2022)

Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction
por: Duttke, Sascha H., et al.
Publicado: (2022)

Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use
por: Smith, Lauren C., et al.
Publicado: (2020)

Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats
por: Wang, Tengfei, et al.
Publicado: (2018)

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
por: de Guglielmo, Giordano, et al.
Publicado: (2019)

Editorial: Opioids and opioid-use disorders
por: de Guglielmo, Giordano, et al.
Publicado: (2023)

Cortico-Amygdala Coupling as a Marker of Early Relapse Risk in Cocaine-Addicted Individuals
por: McHugh, Meredith J., et al.
Publicado: (2014)

Cocaine-Dosage and Cocaine-Addiction
por: Mattison, J. B.
Publicado: (1887)

Dopamine D(3) Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats
por: de Guglielmo, Giordano, et al.
Publicado: (2020)

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster
por: Baker, Brandon M., et al.
Publicado: (2021)

Cocaine Addiction
por: Mattison, J. B.
Publicado: (1886)

Editorial: Insights in motivation and reward - 2022
por: Kallupi, Marsida, et al.
Publicado: (2023)

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats
por: Kononoff, Jenni, et al.
Publicado: (2018)

Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice
por: Tran, Thi Dong Binh, et al.
Publicado: (2023)

The Neurobiology of Cocaine Addiction
por: Nestler, Eric J.
Publicado: (2005)

Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies
por: Gileta, Alexander F., et al.
Publicado: (2022)

GABAergic Gene Expression in Postmortem Hippocampus from Alcoholics and Cocaine Addicts; Corresponding Findings in Alcohol-Naïve P and NP Rats
por: Enoch, Mary-Anne, et al.
Publicado: (2012)

The biological basis of cocaine addiction

Astrocytes in Cocaine Addiction and Beyond
por: Wang, Junshi, et al.
Publicado: (2022)

Forty years on.
por: McVicker, J. A.
Publicado: (1973)

Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala
por: Wang, Guang-Yan, et al.
Publicado: (2016)

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy
por: Sun, Ying, et al.
Publicado: (2019)

Novel pharmacotherapeutic treatments for cocaine addiction
por: Shorter, Daryl, et al.
Publicado: (2011)

The Role of Accumbal Hypoactivity in Cocaine Addiction.
por: Peoples, L. L., et al.
Publicado: (2007)

An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse
por: Kallupi, Marsida, et al.
Publicado: (2018)

Sex Differences in Psychiatric Comorbidity and Plasma Biomarkers for Cocaine Addiction in Abstinent Cocaine-Addicted Subjects in Outpatient Settings
por: Pedraz, María, et al.
Publicado: (2015)

Fear learning triggers structural changes at GABAergic synapses in the basal amygdala
por: Kasugai, Yu, et al.
Publicado: (2010)

Identification and Characterization of GABAergic Projection Neurons from Ventral Hippocampus to Amygdala
por: Lübkemann, Robert, et al.
Publicado: (2015)

Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala
por: Fang, Qing, et al.
Publicado: (2018)

Correction: Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy
por: Sun, Ying, et al.
Publicado: (2019)

Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala
por: Meis, Susanne, et al.
Publicado: (2019)

Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine
por: Isaza, Carlos, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lgm3mn9slc3rvijja7p7a51tb2