Cargando…

Comparative membrane lipidomics of hepatocellular carcinoma cells reveals diacylglycerol and ceramide as key regulators of Wnt/β‐catenin signaling and tumor growth

Hepatocellular carcinoma (HCC) is largely associated with aberrant activation of Wnt/β‐catenin signaling. Nevertheless, how membrane lipid composition is altered in HCC cells with abnormal Wnt signaling remains elusive. Here, by exploiting comprehensive lipidome profiling, we unravel the membrane li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Azbazdar, Yagmur, Demirci, Yeliz, Heger, Guillaume, Ipekgil, Dogac, Karabicici, Mustafa, Ozhan, Gunes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620124/ https://www.ncbi.nlm.nih.gov/pubmed/37699867 http://dx.doi.org/10.1002/1878-0261.13520

Ejemplares similares

Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
por: Azbazdar, Yagmur, et al.
Publicado: (2021)

Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
por: Karabicici, Mustafa, et al.
Publicado: (2021)

Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis
por: Azbazdar, Yagmur, et al.
Publicado: (2023)

Changes in Wnt and TGF-β Signaling Mediate the Development of Regorafenib Resistance in Hepatocellular Carcinoma Cell Line HuH7
por: Karabicici, Mustafa, et al.
Publicado: (2021)

Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage
por: Demirci, Yeliz, et al.
Publicado: (2020)

Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis
por: Ozalp, Ozgun, et al.
Publicado: (2021)

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells
por: Katkat, Esra, et al.
Publicado: (2023)

Wnt3 Is Lipidated at Conserved Cysteine and Serine Residues in Zebrafish Neural Tissue
por: Dhasmana, Divya, et al.
Publicado: (2021)

Brain Regeneration Resembles Brain Cancer at Its Early Wound Healing Stage and Diverges From Cancer Later at Its Proliferation and Differentiation Stages
por: Demirci, Yeliz, et al.
Publicado: (2022)

Wnt/β-catenin signaling in heart regeneration
por: Ozhan, Gunes, et al.
Publicado: (2015)

Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments
por: Sezgin, Erdinc, et al.
Publicado: (2017)

More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains
por: Azbazdar, Yagmur, et al.
Publicado: (2019)

A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver
por: Preuss, Christina, et al.
Publicado: (2019)

SEMA6D Differentially Regulates Proliferation, Migration, and Invasion of Breast Cell Lines
por: Gunyuz, Zehra Elif, et al.
Publicado: (2022)

Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide
por: Murakami, Chiaki, et al.
Publicado: (2021)

Analysis of open chromatin regions in bladder cancer links β-catenin mutations and Wnt signaling with neuronal subtype of bladder cancer
por: Eray, Aleyna, et al.
Publicado: (2020)

Integrated lipidomic and transcriptomic analysis reveals diacylglycerol accumulation in olive of Longnan (China)
por: Hu, Wei, et al.
Publicado: (2023)

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?
por: Amati, Francesca, et al.
Publicado: (2011)

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis
por: Pathak, Divya, et al.
Publicado: (2018)

Editorial: Wnt Signaling at the Plasma Membrane: Activation, Regulation and Disease Connection
por: Ozhan, Gunes
Publicado: (2021)

Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane
por: Deevska, Gergana, et al.
Publicado: (2021)

Egg Yolk Fat Deposition Is Regulated by Diacylglycerol and Ceramide Enriched by Adipocytokine Signaling Pathway in Laying Hens
por: Ji, Qianyun, et al.
Publicado: (2023)

The PMA Phorbol Ester Tumor Promoter Increases Canonical Wnt Signaling Via Macropinocytosis
por: Tejeda-Muñoz, Nydia, et al.
Publicado: (2023)

The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis
por: Tejeda-Munoz, Nydia, et al.
Publicado: (2023)

Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus
por: Lingelem, Anne Berit Dyve, et al.
Publicado: (2020)

Neuroinflammation in Schizophrenia: The Key Role of the WNT/β-Catenin Pathway
por: Vallée, Alexandre
Publicado: (2022)

Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
por: Søgaard, Ditte, et al.
Publicado: (2016)

Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition
por: Sewell, Gavin W., et al.
Publicado: (2012)

Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome
por: McGurk, Kathryn A, et al.
Publicado: (2021)

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
por: Kotronen, Anna, et al.
Publicado: (2009)

Lipidomic profiling reveals biosynthetic relationships between phospholipids and diacylglycerol ethers in the deep-sea soft coral Paragorgia arborea
por: Imbs, Andrey B., et al.
Publicado: (2021)

Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies
por: Park, Hyejung, et al.
Publicado: (2010)

Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats
por: Jani, Shailee, et al.
Publicado: (2021)

Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma
por: Zhang, Guo-Feng, et al.
Publicado: (2020)

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse
por: Gharbi, Severine I., et al.
Publicado: (2011)

Lipidomic Analysis Reveals Specific Differences between Fibroblast and Keratinocyte Ceramide Profile of Patients with Psoriasis Vulgaris
por: Łuczaj, Wojciech, et al.
Publicado: (2020)

Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in apolipoprotein E Knockout Mice
por: Law, Shi-Hui, et al.
Publicado: (2023)

Engineering the Thermostability of the Mono- and Diacylglycerol Lipase SMG1 for the Synthesis of Diacylglycerols
por: Li, Lilang, et al.
Publicado: (2022)

Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility
por: Wang, Bingqi, et al.
Publicado: (2020)

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH
por: Zanieri, Francesca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_59cfr5iacovrlg082kb4qou07p