MTHFR C677T and A1298C polymorphism’s effect on risk of colorectal cancer in Lynch syndrome

Lynch syndrome (LS) is characterised by an increased risk of developing colorectal cancer (CRC) and other extracolonic epithelial cancers. It is caused by pathogenic germline variants in DNA mismatch repair (MMR) genes or the EPCAM gene, leading to a less functional DNA MMR system. Individuals diagn...

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Detalles Bibliográficos
Autores principales: Wiik, Mariann Unhjem, Negline, Mia, Beisvåg, Vidar, Clapham, Matthew, Holliday, Elizabeth, Dueñas, Nuria, Brunet, Joan, Pineda, Marta, Bonifaci, Nuria, Aretz, Stefan, Klinkhammer, Hannah, Spier, Isabel, Perne, Claudia, Mayr, Andreas, Valle, Laura, Lubinski, Jan, Sjursen, Wenche, Scott, Rodney J., Talseth-Palmer, Bente A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620134/
https://www.ncbi.nlm.nih.gov/pubmed/37914736
http://dx.doi.org/10.1038/s41598-023-44120-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620134/
https://www.ncbi.nlm.nih.gov/pubmed/37914736
http://dx.doi.org/10.1038/s41598-023-44120-8

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