An in vitro model of the macrophage-endothelial interface to characterize CAR T-cell induced cytokine storm

Chimeric Antigen Receptor (CAR) T-cell therapy is a highly effective treatment for B-cell malignancies but limited in use due to clinically significant hyperinflammatory toxicities. Understanding the pathophysiologic mechanisms which mediate these toxicities can help identify novel management strate...

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Detalles Bibliográficos
Autores principales: Rosen, Robert S., Yang, Jason H., Peña, Juan S., Schloss, Rene, Yarmush, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620221/
https://www.ncbi.nlm.nih.gov/pubmed/37914765
http://dx.doi.org/10.1038/s41598-023-46114-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620221/
https://www.ncbi.nlm.nih.gov/pubmed/37914765
http://dx.doi.org/10.1038/s41598-023-46114-y

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