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Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine
Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and booster effects of that vaccine over a period representing a mouse’s lifespan. The vaccine remained effective for over one year, and booster vaccinatio...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620388/ https://www.ncbi.nlm.nih.gov/pubmed/37914738 http://dx.doi.org/10.1038/s41541-023-00770-3 |
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| author | Fukami, Hirotaka Morinaga, Jun Nakagami, Hironori Hayashi, Hiroki Okadome, Yusuke Matsunaga, Eiji Kadomatsu, Tsuyoshi Horiguchi, Haruki Sato, Michio Sugizaki, Taichi Miyata, Keishi Torigoe, Daisuke Mukoyama, Masashi Morishita, Ryuichi Oike, Yuichi |
| author_facet | Fukami, Hirotaka Morinaga, Jun Nakagami, Hironori Hayashi, Hiroki Okadome, Yusuke Matsunaga, Eiji Kadomatsu, Tsuyoshi Horiguchi, Haruki Sato, Michio Sugizaki, Taichi Miyata, Keishi Torigoe, Daisuke Mukoyama, Masashi Morishita, Ryuichi Oike, Yuichi |
| author_sort | Fukami, Hirotaka |
| collection | PubMed |
| description | Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and booster effects of that vaccine over a period representing a mouse’s lifespan. The vaccine remained effective for over one year, and booster vaccination maintained suppression of circulating triglyceride levels thereafter without major adverse effects on lungs, kidneys, or liver, suggesting vaccine efficacy and safety. |
| format | Online Article Text |
| id | pubmed-10620388 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106203882023-11-03 Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine Fukami, Hirotaka Morinaga, Jun Nakagami, Hironori Hayashi, Hiroki Okadome, Yusuke Matsunaga, Eiji Kadomatsu, Tsuyoshi Horiguchi, Haruki Sato, Michio Sugizaki, Taichi Miyata, Keishi Torigoe, Daisuke Mukoyama, Masashi Morishita, Ryuichi Oike, Yuichi NPJ Vaccines Brief Communication Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and booster effects of that vaccine over a period representing a mouse’s lifespan. The vaccine remained effective for over one year, and booster vaccination maintained suppression of circulating triglyceride levels thereafter without major adverse effects on lungs, kidneys, or liver, suggesting vaccine efficacy and safety. Nature Publishing Group UK 2023-11-01 /pmc/articles/PMC10620388/ /pubmed/37914738 http://dx.doi.org/10.1038/s41541-023-00770-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Fukami, Hirotaka Morinaga, Jun Nakagami, Hironori Hayashi, Hiroki Okadome, Yusuke Matsunaga, Eiji Kadomatsu, Tsuyoshi Horiguchi, Haruki Sato, Michio Sugizaki, Taichi Miyata, Keishi Torigoe, Daisuke Mukoyama, Masashi Morishita, Ryuichi Oike, Yuichi Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title | Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title_full | Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title_fullStr | Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title_full_unstemmed | Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title_short | Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine |
| title_sort | efficacy and safety in mice of repeated, lifelong administration of an angptl3 vaccine |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620388/ https://www.ncbi.nlm.nih.gov/pubmed/37914738 http://dx.doi.org/10.1038/s41541-023-00770-3 |
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