Cargando…

The EDC4‐XRN1 interaction controls P‐body dynamics to link mRNA decapping with decay

Deadenylation‐dependent mRNA decapping and decay is the major cytoplasmic mRNA turnover pathway in eukaryotes. Many mRNA decapping and decay factors are associated with each other via protein–protein interaction motifs. For example, the decapping enzyme DCP2 and the 5'–3' exonuclease XRN1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brothers, William R, Ali, Farah, Kajjo, Sam, Fabian, Marc R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620763/ https://www.ncbi.nlm.nih.gov/pubmed/37621215 http://dx.doi.org/10.15252/embj.2023113933

Ejemplares similares

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay
por: Brothers, William R, et al.
Publicado: (2020)

P-bodies directly regulate MARF1-mediated mRNA decay in human cells
por: Brothers, William R, et al.
Publicado: (2022)

Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis
por: Malsick, Lauren E, et al.
Publicado: (2023)

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
por: Mugridge, Jeffrey S., et al.
Publicado: (2018)

The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface
por: Wurm, Jan Philip, et al.
Publicado: (2016)

Crosstalk between Edc4 and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in mRNA Decapping
por: Rahman, Hazir, et al.
Publicado: (2014)

The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae
por: Huch, Susanne, et al.
Publicado: (2016)

Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
por: Hernández, Gonzalo, et al.
Publicado: (2018)

Control of mRNA decapping by autoinhibition
por: Paquette, David R, et al.
Publicado: (2018)

Eukaryotic mRNA Decapping Activation
por: Vidya, Elva, et al.
Publicado: (2022)

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay
por: Chang, Chung-Te, et al.
Publicado: (2019)

Interactions between Upf1 and the Decapping Factors Edc3 and Pat1 in Saccharomyces cerevisiae
por: Swisher, Kylie D., et al.
Publicado: (2011)

Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
por: Burgess, Hannah M., et al.
Publicado: (2018)

Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage
por: Wu, Xiaoling, et al.
Publicado: (2020)

A unique mRNA decapping complex in trypanosomes
por: Kramer, Susanne, et al.
Publicado: (2023)

mRNA Decapping and 5′-3′ Decay Contribute to the Regulation of ABA Signaling in Arabidopsis thaliana
por: Wawer, Izabela, et al.
Publicado: (2018)

An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress
por: Huch, Susanne, et al.
Publicado: (2017)

Mutations in genes encoding regulators of mRNA decapping and translation initiation: links to intellectual disability
por: Weil, Dominique, et al.
Publicado: (2020)

A human microprotein that interacts with the mRNA decapping complex
por: D’Lima, Nadia G., et al.
Publicado: (2016)

Application of a Schizosaccharomyces pombe Edc1-fused Dcp1–Dcp2 decapping enzyme for transcription start site mapping
por: Paquette, David R., et al.
Publicado: (2018)

A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping
por: Schütz, Stefan, et al.
Publicado: (2017)

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2
por: Davidson, Lee, et al.
Publicado: (2012)

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability
por: Scheller, Ute, et al.
Publicado: (2018)

Nudt3 is an mRNA decapping enzyme that modulates cell migration
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2016)

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
por: Tibble, Ryan W., et al.
Publicado: (2021)

The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation
por: Chuang, Tzu-Wei, et al.
Publicado: (2013)

Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS
por: Taverniti, Valerio, et al.
Publicado: (2015)

Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme
por: Fuchs, Anna-Lisa, et al.
Publicado: (2020)

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1
por: Chang, Chung-Te, et al.
Publicado: (2014)

Membrane-association of mRNA decapping factors is independent of stress in budding yeast
por: Huch, Susanne, et al.
Publicado: (2016)

Ago-TNRC6 complex triggers microRNA-mediated mRNA decay by promoting biphasic deadenylation followed by decapping
por: Chen, Chyi-Ying A., et al.
Publicado: (2009)

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)
por: Gunawardana, Dilantha, et al.
Publicado: (2008)

In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery**
por: Fromm, Simon A, et al.
Publicado: (2014)

3′ uridylation precedes decapping in a novel pathway of bulk mRNA turnover
por: Rissland, Olivia S., et al.
Publicado: (2009)

The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa
por: Braun, Joerg E, et al.
Publicado: (2010)

Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms
por: Wurm, Jan Philip, et al.
Publicado: (2019)

mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing
por: Borbolis, Fivos, et al.
Publicado: (2020)

Is mRNA decapping by ApaH like phosphatases present in eukaryotes beyond the Kinetoplastida?
por: Castañeda Londoño, Paula Andrea, et al.
Publicado: (2021)

Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay
por: Kolesnikova, Olga, et al.
Publicado: (2013)

The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4
por: Begley, Victoria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s5mfoltk0ft0im6ii5qn9klvth