Utilizing Heteroatom Types and Numbers from Extensive Ligand Libraries to Develop Novel hERG Blocker QSAR Models Using Machine Learning-Based Classifiers

[Image: see text] The human ether-à-go-go-related gene (hERG) channel plays a crucial role in membrane repolarization. Any disruptions in its function can lead to severe cardiovascular disorders such as long QT syndrome (LQTS), which increases the risk of serious cardiovascular problems such as tach...

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Detalles Bibliográficos
Autores principales: Haddad, Safa, Oktay, Lalehan, Erol, Ismail, Şahin, Kader, Durdagi, Serdar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620895/
https://www.ncbi.nlm.nih.gov/pubmed/37929100
http://dx.doi.org/10.1021/acsomega.3c06074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620895/
https://www.ncbi.nlm.nih.gov/pubmed/37929100
http://dx.doi.org/10.1021/acsomega.3c06074

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