Discovery of Chemical Scaffolds as Lysophosphatidic Acid Receptor 1 Antagonists: Virtual Screening, In Vitro Validation, and Molecular Dynamics Analysis

[Image: see text] Lysophosphatidic acid receptor 1 (LPAR1) is an emerging therapeutic target for numerous human diseases including fibrosis. However, the limited number of available core structures of LPAR1 antagonists has prompted the need for novel chemical templates. In this study, we conducted a...

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Detalles Bibliográficos
Autores principales: Nguyen, Lan Phuong, Khan, Rasel Ahmed, Kang, Soomin, Lee, Hobin, Hwang, Jong-Ik, Kim, Hong-Rae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620911/
https://www.ncbi.nlm.nih.gov/pubmed/37929144
http://dx.doi.org/10.1021/acsomega.3c04798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620911/
https://www.ncbi.nlm.nih.gov/pubmed/37929144
http://dx.doi.org/10.1021/acsomega.3c04798

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