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Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia

BACKGROUND: Allogeneic hematopoietic stem cell transplant remains the most effective strategy for patients with high-risk acute myeloid leukemia (AML). Leukemia-specific neoantigens presented by the major histocompatibility complexes (MHCs) are recognized by the T cell receptors (TCR) triggering the...

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Detalles Bibliográficos
Autores principales: Pospiech, Mateusz, Tamizharasan, Mukund, Wei, Yu-Chun, Kumar, Advaith Maya Sanjeev, Lou, Mimi, Milstein, Joshua, Alachkar, Houda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620936/
https://www.ncbi.nlm.nih.gov/pubmed/37928542
http://dx.doi.org/10.3389/fimmu.2023.1236514