Cargando…

Synthesis and Evaluation of 9-Aminoacridines with SARS-CoV-2 Antiviral Activity

[Image: see text] There have been relatively few small molecules developed with direct activity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two existing antimalarial drugs, pyronaridine and quinacrine, display whole cell activity against SARS-CoV-2 in A549 + ACE2 cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jones, Thane, Monakhova, Natalia, Guivel-Benhassine, Florence, Lepioshkin, Alexander, Bruel, Timothée, Lane, Thomas R., Schwartz, Olivier, Puhl, Ana C., Makarov, Vadim, Ekins, Sean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620940/ https://www.ncbi.nlm.nih.gov/pubmed/37929131 http://dx.doi.org/10.1021/acsomega.3c05900

Ejemplares similares

1-Sulfonyl-3-amino-1H-1,2,4-triazoles as Yellow Fever Virus Inhibitors: Synthesis and Structure–Activity Relationship
por: Kazakova, Elena, et al.
Publicado: (2023)

Reproductive toxicology. 9-Aminoacridine hydrochloride.
Publicado: (1997)

The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells
por: Casartelli, Nicoletta, et al.
Publicado: (2010)

Kinetics of 9-aminoacridine block of single Na channels
Publicado: (1984)

Dynamics of 9-aminoacridine block of sodium channels in squid axons
Publicado: (1979)

9-aminoacridine Inhibition of HIV-1 Tat Dependent Transcription
por: Guendel, Irene, et al.
Publicado: (2009)

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells
por: Dufloo, Jérémy, et al.
Publicado: (2022)

Elimination of HIV-1-infected cells by broadly neutralizing antibodies
por: Bruel, Timothée, et al.
Publicado: (2016)

9-Aminoacridin-10-ium 4-aminobenzoate dihydrate
por: Dhanabalan, Nallathambi, et al.
Publicado: (2014)

Antibacterial and Photocatalytic Properties of ZnO–9-Aminoacridine Hydrochloride Hydrate Drug Nanoconjugates
por: Mitra, Piyali, et al.
Publicado: (2018)

9-Aminoacridine Inhibits Ribosome Biogenesis by Targeting Both Transcription and Processing of Ribosomal RNA
por: Anikin, Leonid, et al.
Publicado: (2022)

Complexes of Pd(II) and Pt(II) with 9-Aminoacridine: Reactions with DNA and Study of Their Antiproliferative Activity
por: Riera, X., et al.
Publicado: (2007)

HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer
por: Malbec, Marine, et al.
Publicado: (2013)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2020)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2021)

Transporter Inhibition Profile for the Antivirals Tilorone, Quinacrine and Pyronaridine
por: Vignaux, Patricia A., et al.
Publicado: (2023)

Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae
por: She, Pengfei, et al.
Publicado: (2023)

Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)
por: Egorova, Anna, et al.
Publicado: (2021)

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells
por: Planchais, Cyril, et al.
Publicado: (2019)

A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice
por: Mangueira, Vivianne M., et al.
Publicado: (2022)

Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission
por: Casartelli, Nicoletta, et al.
Publicado: (2010)

Antiviral activities of sotrovimab against BQ.1.1 and XBB.1.5 in sera of treated patients
por: Bruel, Timothée, et al.
Publicado: (2023)

Duration of BA.5 neutralization in sera and nasal swabs from SARS-CoV-2 vaccinated individuals, with or without omicron breakthrough infection
por: Planas, Delphine, et al.
Publicado: (2022)

Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemia
por: Ju, Wei, et al.
Publicado: (2014)

Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond
por: Ekins, Sean, et al.
Publicado: (2020)

Correction to: Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond
por: Ekins, Sean, et al.
Publicado: (2020)

Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions
por: Shiraishi, Takehiko, et al.
Publicado: (2010)

Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells
por: Monel, Blandine, et al.
Publicado: (2017)

A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis
por: Salina, Elena G., et al.
Publicado: (2022)

The past, present and future of RNA respiratory viruses: influenza and coronaviruses
por: Makarov, Vadim, et al.
Publicado: (2020)

Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
por: Palha, Nuno, et al.
Publicado: (2013)

Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
por: Ekins, Sean, et al.
Publicado: (2020)

Editor's note on ‘down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine–PNA (peptide nucleic acid) conjugates’
Publicado: (2023)

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
por: Dufloo, Jérémy, et al.
Publicado: (2018)

Chikungunya virus–induced autophagy delays caspase-dependent cell death
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2012)

Small molecules with antiviral activity against the Ebola virus
por: Litterman, Nadia, et al.
Publicado: (2015)

Novel Aminoacridine Sensors Based on Molecularly Imprinted Hybrid Polymeric Membranes for Static and Hydrodynamic Drug Quality Control Monitoring
por: S. M. Hassan, Saad, et al.
Publicado: (2019)

The Evolution of Pleconaril: Modified O-Alkyl Linker Analogs Have Biological Activity towards Coxsackievirus B3 Nancy
por: Volobueva, Alexandrina, et al.
Publicado: (2020)

Benzoylphenyl thiocyanates are new, effective inhibitors of the mycobacterial resuscitation promoting factor B protein
por: Demina, Galina R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_aduim0chet1j00dv1gqcnqji51